Srinagar: Glenmark Pharmaceuticals Ltd (Glenmark), a research-led global integrated pharmaceutical company,announced the launch of its novel,patent protected and globally-researched sodium glucose co-transporter (SGLT2)inhibitor Remogliflozinetabonate(Remogliflozin) in India. The drug is indicated in the treatment of type-2 diabetes mellitus in adults.
SGLT2 inhibitors are novel anti-diabetic drugs that help achieve glycemic control by acting on the SGLT2 receptors in the proximal convoluted tubule of the kidney, thereby preventing renal reabsorption of glucose and promoting excretion of glucose in the urine. Along with providing glycemic control, SGLT2 inhibitors help induce weight loss and reduce cardiovascular risks.
Glenmark is the first company in the world to launch Remogliflozinand India is the first country to get access to this innovative drug. Glenmark has launched Remogliflozin in Indiaunder brand names “Remo” and “Remozen”. Remogliflozinis the only SGLT2 inhibitor to be manufactured in India from active pharmaceutical ingredient (API) to formulation.
The company has launched Remogliflozinat a breakthrough price of Rs. 12.50 per tablet, twice daily, which is over 50% lower than the existing SGLT2 inhibitors available in India. Currently, the average per day therapy cost of SGLT2 inhibitors in India is about Rs. 55. Remogliflozin offers saving of about Rs. 11,000 per year for diabetes patients on SGLT2 inhibitors.
Glenmark received regulatory approval for Remogliflozinetabonate 100 mg after successfully completing Phase-3 clinical trials in which Remogliflozin demonstrated good efficacy and safety profile in a head-to-head comparison against Dapagliflozin.
Remogliflozin has been studied in 26 clinical trials globally, covering around 2,500 patients from various ethnicities. Remogliflozin was discovered and developed by Japanese firm Kissei Pharmaceutical Co. Ltd. and later developed by GlaxoSmithKline plc and Glenmark collaborator BHV Pharma, a wholly owned subsidiary of Avolynt, Inc. which is based in North Carolina, USA. Glenmark secured certain rights to Remogliflozin through a licensing collaboration agreement with BHV Pharma, and conducted the Phase-3 clinical trial, which included the largest number of Indian patients tested for any SGLT2 inhibitor.
“Globally, SGLT2 inhibitors are emerging as a preferred treatment for management of type-2 diabetes and Glenmark is proud to introduce an innovative molecule in this class, which is cutting-edge and researched extensively. Glenmark has been a pioneer in providing access to the latest treatment options to diabetes patients in India at a relatively low cost and with the launch of Remogliflozin, the company aims to increase patients’ access to SGLT2 inhibitors as this class of drugs have proven benefits for effective diabetes management,” said Sujesh Vasudevan, President, India Formulations, Middle East and Africa at Glenmark Pharmaceuticals.